Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
✍ Scribed by Oubridge, Chris; Ito, Nobutoshi; Evans, Philip R.; Teo, C.-Hiang; Nagai, Kiyoshi
- Book ID
- 109790487
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 831 KB
- Volume
- 372
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/372432a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A novel ligand‐binding site with functional implications has been identified in phospholipase A~2~ (PLA~2~). The binding of non‐steroidal anti‐inflammatory agent indomethacin at this site blocks both catalytic and anti‐coagulant actions of PLA~2~. A group IIA PLA~2~ has been isolated fr
Phospholipase A 2 (PLA 2 ) enzymes from snake venoms are approximately 14 kDa secretory proteins and catalyze the release of arachidonic acid which is the precursor of proinflammatory mediators such as prostaglandins, leukotrienes, thromboxanes and plateletactivating factors. The structure of the PL