𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Crystal forms of LY334370 HCl: Isolation, solid-state characterization, and physicochemical properties

✍ Scribed by Susan M. Reutzel-Edens; Rita L. Kleemann; Peggy L. Lewellen; Alfio L. Borghese; Luc J. Antoine

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
297 KB
Volume
92
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

LY334370 HCl, a 5HT1f agonist investigated for the treatment of migraines, was identified in five crystal forms: three anhydrates (I-III), a dihydrate, and an acetic acid solvate. The identification and characterization of these crystal forms by optical microscopy, differential scanning calorimetry, thermogravimetric and moisture sorption analyses, solid-state NMR spectroscopy, and X-ray crystallography (Form I only) are presented. Physical properties, including hygroscopicity, solubility, and intrinsic dissolution rate, were assessed for Form I and the dihydrate, the two most viable crystal forms for commercial development. Surprisingly, anhydrous Form I was found to be the thermodynamically most stable crystal form in water, dissolving six times slower than the dihydrate, a difference that correlates well with the rank order of aqueous solubility.

📜 SIMILAR VOLUMES

Structural characterization, physicochem
Structural characterization, physicochemical properties, and thermal stability of three crystal forms of nifedipine
✍ Mino R. Caira; Yolande Robbertse; Jacobus J. Bergh; Mingna Song; Melgardt M. De 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 272 KB

In this study the single-crystal X-ray structure of the solvated species (nifedipine)2. 1,4-dioxane is reported for the first time. Included solvent molecules are located in isolated cavities in the crystal, yielding a very stable solvate. Desolvation of this species involves complete disruption of

Solid state characterization and crystal
Solid state characterization and crystal structure from X-ray powder diffraction of two polymorphic forms of ranitidine base
✍ Héctor Novoa de Armas; Oswald M. Peeters; Norbert Blaton; Elke Van Gyseghem; Joh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

Ranitidine hydrochloride (RAN-HCl), a known anti-ulcer drug, is the product of reaction between HCl and ranitidine base (RAN-B). RAN-HCl has been extensively studied; however this is not the case of the RAN-B. The solid state characterization of RAN-B polymorphs has been carried out using different