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Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

✍ Scribed by Almarsson, �rn; Zaworotko, Michael J.


Book ID
120231959
Publisher
Royal Society of Chemistry
Year
2004
Tongue
English
Weight
897 KB
Volume
17
Category
Article
ISSN
1359-7345

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Crystal engineering of the composition o
✍ McMahon, Jennifer A.; Bis, Joanna A.; Vishweshwar, Peddy; Shattock, Tanise R.; M 📂 Article 📅 2005 🏛 Oldenbourg Wissenschaftsverlag 🌐 English ⚖ 530 KB

## Abstract A Cambridge Structural Database study of supramolecular synthons involving primary amides reveals that 84% form amide-amide dimers, whereas 14% form catemers in the absence of other competing hydrogen bond donors and/or acceptors. However in the presence of chemically different but comp