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Crystal and molecular structure of 1α-hydroxylated analogs of vitamins D

✍ Scribed by Waclaw Kolodziejski; Krzysztof Woźniak; Joanna Herold; Paulina M. Dominiak; Andrzej Kutner

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
351 KB
Volume
734
Category
Article
ISSN
0022-2860

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✦ Synopsis

Structures of two 1a-hydroxylated analogs of vitamins D, 1a-hydroxycholecalciferol and 1a-hydroxyergocalciferol, were solved and refined using single crystal X-ray diffraction. Crystallographic results are verified by 13 C CP/MAS NMR. This method provided also information on molecular mobility of analogs.

In the crystal state, both molecules adopt exclusively a chair b-conformation of the 6-member ring A. It has been suggested that this conformation is preferred, when vitamin D molecules participate in hydrogen bonding. This is consistent with the earlier hypothesis that the b-conformers are involved in the interaction of vitamins D with their receptors.

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