Recent studies suggest that hepatocyte growth factor (HGF) functions as a neurotrophic factor in the central nervous system. In this study, we investigated the neuroprotective effect of HGF and its mechanism of action. We used cultured cerebellar granule neurons that underwent apoptosis when the cul
✦ LIBER ✦
Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway
✍ Scribed by Fangyan Zhang; Wenhua Zheng; Rongbiao Pi; Zhengrong Mei; Yingxia Bao; Jie Gao; Wenjie Tang; Shaorui Chen; Peiqing Liu
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 648 KB
- Volume
- 193
- Category
- Article
- ISSN
- 0014-4819
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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re