Cryptococcus neoformansvarieties as agents of cryptococcosis in Brazil

✍ Scribed by Ronaldo Rozenbaum; Adrelirio José Rios Gonçalves; Bodo Wanke; Maria Julieta Caiuby; Hamilton Clemente; Marcia dos Santos Lazera; Paulo Cesar Fialho Monteiro; Alberto Thomaz Londero

• Publisher: Springer Netherlands
• Year: 1992
• Tongue: English
• Weight: 317 KB
• Volume: 119
• Category: Article
• ISSN: 0301-486X
• DOI: 10.1007/bf00448809

✦ Synopsis

The study of the clinical isolates of Cryptococcus neoformans from 83 Brazilian patients with disseminated cryptococcosis showed that 75 were C. neoformans var. neoformans and 8 were var. gattii. Twentyseven isolates were serotyped; all 19 var. neoformans were serotype A and all 8 var. gattii were serotype B. The correlation of the varieties of C. neoformans with the presence or not of hosts predisposing conditions to the mycosis showed that: (1) cryptococcosis caused by gattii variety occurred in 7 (58.3%) of the 12 nonimmunosuppressed patients, and (2) cryptococcosis caused by neoformans variety occurred in 65 (98.5%) of the 66 AIDS patients and in all 5 patients with other immunosuppressive conditions.

The comparison of the distribution of the gattii and neoformans varieties between the nonimmunosuppressed and immunosuppressed patients showed a significant statistical difference (p < 0.01).