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Cryptic variants of acrocentric human chromosomes as analysed by restriction endonucleases

✍ Scribed by S. F. Cabo; P. Ludeña; M. Velázquez; C. Sentis; J. Fernández-Piqueras

Publisher: Springer Netherlands
Year: 1991
Tongue: English
Weight: 590 KB
Volume: 83
Category: Article
ISSN: 0016-6707
DOI: 10.1007/bf00126226

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✦ Synopsis

Ten phenotypically normal human individuals have been analysed by in situ treatments with restriction endonucleases in order to obtain a better characterization of some cryptic variants of acrocentric chromosomes. Treatments with AluI, NdeII and Sau3AI confirm the existence of two cryptic amplified regions on the short arms of both one chromosome 15 and one chromosome 22, in one female. These amplitications seem to be of different origin involving the nucleolar organizer region of chromosome 15 and the satellite of chromosome 22.

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