๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Cryotherapy for neuroendocrine liver metastases

โœ Scribed by Joachim K. Seifert; Paul J. Cozzi; David L. Morris

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
233 KB
Volume
14
Category
Article
ISSN
8756-0437

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โœฆ Synopsis

While the prognosis for patients with untreated liver metastases from neuroendocrine primaries is rather good, they often suffer disabling symptoms due to syndromes of hormonal excess. Thirteen patients with metastatic neuroendocrine tumours were treated by hepatic cryotherapy; seven patients were symptomatic and five of these had elevated levels of hormonal tumour markers. Twelve patients are alive and mostly asymptomatic with a median follow up of 13.5 months; one patient died after 45 months of bronchopneumonia without evidence of tumour recurrence. All patients with elevated preoperative tumour markers have had a significant fall in markers postoperatively. Two patients were returned to the operating theatre for coagulopathy-associated bleeding: one patient each developed acute renal failure and pulmonary embolism, but there was no mortality. This study shows that hepatic cryotherapy offers a useful treatment option for this group of patients, alleviates symptoms and may have an impact on survival.

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