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Cryoprotection mechanisms of polyethylene glycols on lactate dehydrogenase during freeze-thawing

✍ Scribed by Yanli Mi; George Wood; Laura Thoma

Book ID
119986549
Publisher
American Association of Pharmaceutical Scientists
Year
2004
Tongue
English
Weight
346 KB
Volume
6
Category
Article
ISSN
1550-7416

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Study of the individual contributions of ice formation and freeze-concentration on isothermal stability of lactate dehydrogenase during freezing
✍ Bakul S. Bhatnagar; Michael J. Pikal; Robin H. Bogner πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 245 KB πŸ‘ 1 views

The objective of this study was to determine the individual contributions of ice formation, solute concentration, temperature, and time, to irreversible protein denaturation during freezing. A temperature-step approach was used to study isothermal degradation of frozen lactate dehydrogenase (LDH). T