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Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

✍ Scribed by Simsek, Deniz; Furda, Amy; Gao, Yankun; Artus, Jérôme; Brunet, Erika; Hadjantonakis, Anna-Katerina; Van Houten, Bennett; Shuman, Stewart; McKinnon, Peter J.; Jasin, Maria


Book ID
109900402
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
339 KB
Volume
471
Category
Article
ISSN
0028-0836

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## Abstract Concurrent activation of poly (ADP‐ribose) polymerase (PARP) and DNA ligase was observed in cultured human epidermal keratinocytes (HEK) exposed to the DNA alkylating compound sulfur mustard (SM), suggesting that DNA ligase activation could be due to its modification by PARP. Using HEK,