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Crosstalk Between the Renin–Angiotensin System and the Advance Glycation End Product Axis in the Heart: Role of the Cardiac Fibroblast

✍ Scribed by Katrina Go Yamazaki, Eileen Gonzalez, Alexander C. Zambon


Book ID
118824957
Publisher
Springer US
Year
2012
Tongue
English
Weight
441 KB
Volume
5
Category
Article
ISSN
1937-5387

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Multiligand receptor for advanced glycation end products (RAGE) is expressed in a wide variety of tissues, including the liver. Interactions with its ligands lead to cellular activation and thus prolonged inflammation and apoptosis. RAGE also exists in a soluble, truncated isoform called soluble RAG