## Abstract The present study was undertaken to investigate the regulation of P12^CDK2AP1^ by miRNAs. A conserved target site for miR‐21 within the __CDK2AP1__‐3′‐UTR at nt 349–370 was predicted by bioinformatics software and an inverse correlation of miR‐21 and __CDK2AP1__ protein was observed. Hi
✦ LIBER ✦
Crosstalk between the cell cycle regulator Cdk2 and the Cdx2 tumor suppressor at the proliferation–differentiation interface
✍ Scribed by Gespach, Christian
- Book ID
- 110070118
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 68 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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Genes encoding cdkl (~34'~''), cyclin A, cyclin B, and the tumor suppressor gene Rb are fundamental regulators of cell cycle progression which associate as a complex with the transcription factor E2F. Expression of many of these proteins has previously been shown to be repressed by okadaic acid, a s