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Crosstalk between Myc and activating transcription factor 2 (ATF2): Myc prolongs the half-life and induces phosphorylation of ATF2

✍ Scribed by Miethe, Josef; Schwartz, Claudia; Wottrich, Katja; Wenning, Dorit; Klempnauer, Karl-Heinz


Book ID
110066198
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
283 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) Ξ± is mainly produced in cells from the monocyte/macrophage lineage. TNFΞ± is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFΞ±