Previous studies have demonstrated the immunomodulatory effects of cisplatin under certain conditions. The present study was designed to clarify whether cisplatin modulates the expression of surface antigens, especially human leukocyte antigen (HLA), on human tumor cell lines and/or augments the sus
✦ LIBER ✦
Crosslinking of chromosomal antigen common in human tumors to DNA by cis-diamminedichloroplatinum (II)
✍ Scribed by R. Oliński; Z. Wojtkowiak
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 460 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0301-4851
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The combination of cis-diamminedichloroplatinum(ll) (CDDP) and 7-ethyl-I0-[4-( I -pipmidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To eluc