Crosslinking of Adjacent Guanine Residues in an Oligonucleotide by cis-[Pt(NH3)2(H2O)2]2+: Kinetic Analysis of the Two-Step Reaction

The Kinetics of Substitution Reactions o

The Kinetics of Substitution Reactions of Mixed Platinum(II)–Bis(nucleoside) Complexes in Aqueous Solution in the Presence of Thiourea; X-Ray Crystal Structure Determination of cis-[Pt(NH3)2(adenosine-N7)2](ClO4)2⋅3.5 H2O

✍ Marjaana Mikola; Karel D. Klika; Jorma Arpalahti 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 2 views

In aqueous solution, bis(nucleoside) complexes formed by the reaction of cis-[Pt(NH3)2(H2O)2]2+ with an excess of either adenosine (ado) or a mixture of adenosine and guanosine (guo) undergo a slow N7--> N1 linkage isomerisation in the adenine moiety. The isomerisation probably involves the breaking