✦ LIBER ✦

Crosslinking and cleavage of pBR322 DNA photosensitized by 7-methylpyrido[3,4-c]psoralen

✍ Scribed by Xinsheng Chen; Jacques Kagan

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 986 KB
Volume: 23
Category: Article
ISSN: 1011-1344
DOI: 10.1016/1011-1344(93)06979-d

No coin nor oath required. For personal study only.

✦ Synopsis

7-Methylpyrido[3,4-c]psoralen (7-MPP) had been designed to be a monofunctional sensitizer in which the pyrone double bond, being engaged in a pyridine ring, would be incapable of participating in the formation of a cyclobutane ring with a DNA component. However, one example of photosensitization of thymine-thymine dimer formation in DNA by 7-MPP had been reported. This paper proves that 7-MPP can sensitize interstrand crosslinks in pBR322 DNA. It also proves that 7-MPP photosensitizes double strand cleavage reactions in the DNA with an unusually large degree of site selectivity.

📜 SIMILAR VOLUMES

Photosensitized cross-linking and cleava

Photosensitized cross-linking and cleavage of pBR322 and M13 DNA: Comparison of 4,4′,6-trimethylangelicin and 3-carbethoxypsoralen

✍ X. Chen; J. Kagan; G. Miolo; F. Dall'Acqua; D. Averbeck; E. Bisagni 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 882 KB

Repair of the two diastereoisomer photoa

Repair of the two diastereoisomer photoadducts formed between 7-methylpyrido(3,4-c)psoralen (MePyPs) and thymidine in yeast cells: A chemical approach

✍ M. Dardalhon; A. Moysan; D. Averbeck; P. Vigny 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 649 KB

When analysing the repair of psoralen plus UVA-induced photoadducts in DNA, it must be realized that, in most cases, different isomers are formed. The monofunctional psoralen derivative 7-methylpyrido(3,4-c)psoralen (MePyPs) is known for its high antiproliferative activity at the cellular level and