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Crosslinked hemoglobin inhibits endothelium-dependent relaxations in isolated canine arteries

✍ Scribed by Zvonimir S. Katušić; Henry C. Lee; Eric T. Clambey

Book ID
113328873
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
575 KB
Volume
27
Category
Article
ISSN
0306-3623

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HN-10200 causes endothelium-independent
HN-10200 causes endothelium-independent relaxations in isolated canine arteries
✍ Francesco Cosentino; Alexander Schirger; Zvonimir S. Katušić 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 577 KB

HN-10200, a nonselective inhibitor of phosphodiesterase, has positive inotropic and vasodilator activity. The present study was designed to determine the role of endotheliumin in causing relaxation to HN-10200 in isolated canine femoral and basilar arteries. Rings with and without endothelium were s