## Abstract Colchicine resistant (CH^R^) mutants of CHO cells with reduced permeability to colchicine display extensive crossβresistance to a number of apparently unrelated compounds including puromycin, daunomycin, emetine, ethidium bromide and gramicidin D. A positive correlation was observed bet
β¦ LIBER β¦
Crossed resistance of tumor cells with high resistance to colchicine
β Scribed by R. I. Abdryashitov; A. A. Stavrovskaya
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 257 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0007-4888
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## Abstract Colchicine resistant (CH^R^) lines of stable phenotype have been isolated from cultured Chinese hamster (CHO) cells. Successive singleβstep selections for increasing resistance were performed by isolating resistant colonies at each step. Two complementary assays involving [^3^H] colchic