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Cross-talk between signaling pathways in murine embryonic palate cells: Effect of TGFβ and cAMP on EGF-induced DNA synthesis

✍ Scribed by Wayde M. Weston; Merle B. Potchinsky; Cynthia M. Lafferty; Linh Ma; Robert M. Greene

Book ID
107427571
Publisher
Society for In Vitro Biology
Year
1998
Tongue
English
Weight
559 KB
Volume
34
Category
Article
ISSN
1475-2689

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In mouse C3H 10T1/2 cells, we previously reported that TGF-beta1 first delays and later potentiates EGF-induced DNA synthesis corresponding to an inhibition of EGF-induced cyclin D1 expression at t = 13 h. We report here that in accord with DNA synthesis kinetics, TGF-beta1 initially suppresses EGF-