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Cross-talk between protein kinase C and protein kinase a down-regulates the respiratory burst in polymorphonuclear leukocytes

✍ Scribed by G. Savitha; Bharathi P. Salimath

Book ID
113388579
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
655 KB
Volume
5
Category
Article
ISSN
0898-6568

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo