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Cross-restriction of a T cell clone to HLA–DR alleles associated with rheumatoid arthritis: Clues to arthritogenic peptide motifs

✍ Scribed by Simon Hawke; Hidenori Matsuo; Michael Nicolle; Paul Wordsworth; Louise Corlett; Edward Spack; Shrikant Deshpande; Paul C. Driscoll; Nicholas Willcox

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
194 KB
Volume
42
Category
Article
ISSN
0004-3591

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T cell responses to a human cartilage au
T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis–associated and nonassociated HLA–DR4 alleles
✍ Andrew P. Cope; Salil D. Patel; Frances Hall; Mauro Congia; Henk A. J. M. Hubers 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

Objective. To analyze the CD4؉ ؉ ؉ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DR␣␤1\*0401) and nonassociated (DR␣␤1\*0402) HLA class II molecules. Methods. Large numbers of HCgp-39-specific T cell hybridomas were