Cross-resistance to alkylating agents in multiple myeloma
✍ Scribed by Joan Bladé; Evarist Feliú; Ciril Rozman; Jordi Estapé; Alfredo Millá; Emili Montserrat
- Book ID
- 101326350
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 366 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0008-543X
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Sixteen patients with multiple myeloma refractory to alkylating agents were treated with vincristine 0.25 mg/m2 i.v. on days 1 to 4 and prednisone 1 gm/m2 on days 1 and 3. Chemotherapy was repeated every 2 weeks. Of 15 evaluable patients, five achieved a partial response and four stable disease. Thr
Multiple myeloma is still not curable and drug combination strategies are currently being evaluated in order to achieve high remission rates with tolerable toxicity. Bortezomib has been shown to exert inhibitory effects on NFB activity. NFB in turn is known to be activated by cytokines, growth facto