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Cross-regulation between FOXA1 and ErbB2 Signaling in Estrogen Receptor-Negative Breast Cancer

โœ Scribed by Naderi, Ali; Meyer, Michelle; Dowhan, Dennis H.

Book ID
122283989
Publisher
Neoplasia Press
Year
2012
Tongue
English
Weight
1003 KB
Volume
14
Category
Article
ISSN
1522-8002

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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/