Cross-reactivity between human and murine lymphocyte antigens

✍ Scribed by Vito Quaranta; Michele A. Pellegrino; Gerald N. Callahan; Soldano Ferrone

• Book ID: 104741189
• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 467 KB
• Volume: 13
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00364496

✦ Synopsis

The anti-H-2 alloantiserum D-32 [(B10.A(2R) x C3H.SW) anti-C3H] is cytolytic to human lymphocytes. Fab2 blocking assays, indirect immunoprecipitation and sequential immunoprecipitation experiments showed that the anti-H-2 alloantiserum D-32 recognizes antigenic determinants which are expressed on the heavy chain of subpopulations of HLA-A, B antigens. These determinants are different from those defining the serological polymorphism of the HL4-A, B, C system, are the same as or spatially close to those recognized by the anti-HLA-A, B monoclonal antibody Q6/64 and are expressed on rabbit, rat or guinea pig lymphocytes.