Cross-reactivities of cyclosporin G (NVa2 cyclosporin) and metabolites in cyclosporine A immunoassays
β Scribed by L. Langman; D. LeGatt; R. Yatscoff
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 106 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0009-9120
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π SIMILAR VOLUMES
Cyclosporin A (CSA) is an effective inhibitor of the Pglycoprotein (P-gp) activity and has been shown to modulate multidrug resistance (MDR) in in vitro experimental models. During degradation of CSA, the metabolites arising from the parental compound reach high levels in the serum of patients, and
Seven purified cyclosporine (CsA) metabolites were analyzed for binding to cyciophilin and to a 50 kDa protein purified from a JURKAT cell line. In addition, the potency of the seven metabolites, relative to CsA, was obtained using a primary mixed lymphocyte culture (MLC) suppression assay. CsA, M1,