Cross-national comparison and validation of the Alzheimer's Disease Assessment Scale: results from the European Harmonization Project for Instruments in Dementia (EURO-HARPID)

✍ Scribed by Frans R. Verhey; Peter Houx; Natascha van Lang; Felicia Huppert; Gabriella Stoppe; Jos Saerens; Peter Böhm; Luc de Vreese; Arto Nordlund; Peter P. DeDeyn; Mirco Neri; Jordi Peña-Casanova; Anders Wallin; Eduard Bollen; Huub Middelkoop; Marie-Christine Nargeot; Michèle Puel; Ulrich M. Fleischmann; Jellemer Jolles

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 94 KB
• Volume: 19
• Category: Article
• ISSN: 0885-6230
• DOI: 10.1002/gps.1035

✦ Synopsis

Abstract

Background

The Alzheimer's Disease Assessment Scale (ADAS) is often used in international multicenter trials. Use across countries presupposes correct translation and adaptation of the scale, and maintenance of its psychometric properties.

Objectives

To compare the various translations of the ADAS used in Western Europe, to design internationally harmonized translations and to validate these.

Setting

International cooperative study in eight European countries.

Methods

An inventory was made of existing versions of the ADAS‐Cog used in eight European countries, and adaptations were made. The concurrent validity of the harmonized versions of the ADAS was tested in 283 patients with probable or possible Alzheimer's disease. The Nurses Observation Scale for Geriatrics (NOSGER), CAMCOG‐R and MMSE was used to assess concordance between cognitive and behavioral measures.

Results

Differences between the versions mainly involved object naming, items for verbal memory, such as the number of trials allowed, the imagery value of the words selected as targets or distractors, and the number of parallel versions. These differences were eliminated by adapting and harmonizing the various versions of the ADAS‐Cog. Thereafter, only small differences between the different countries were found, and patterns of correlation between ADAS‐Cog, and the NOSGER, CAMCOG‐R and MMSE were consistent.

Conclusions

The study underlines the need to use harmonized versions of instruments for rating dementia in multinational studies. The findings indicate that the harmonization of the ADAS‐Cog was successful. Copyright © 2004 John Wiley & Sons, Ltd.