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Cross Mannich Reaction of Aldehydes: Efficient Synthesis of Substituted Pyridines.

✍ Scribed by Andreas Winter; Nikolaus Risch

Book ID
101952303
Publisher
John Wiley and Sons
Year
2004
Weight
103 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract The present new facile and convenient synthesis of substituted pyridines involves a one‐pot four‐component reaction of easily available 1,3‐dicarbonyl compounds, aromatic aldehydes, malononitrile and alcohol in the presence of NaOH under mild conditions.