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Cross-link repair in mammalian cells and its impairment in Fanconi's anemia cells

✍ Scribed by Y. Fujiwara; M.S. Sasaki

Book ID
113249038
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
66 KB
Volume
46
Category
Article
ISSN
0165-1161

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## Abstract Interstrand cross‐links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross‐linking agents are well established in clinical use, and numero