Cross-interaction between PAR-activation and tyrosine kinase in the modulation of rat ileum smooth muscle contraction

Effect of Modulators of Tyrosine Kinase

Effect of Modulators of Tyrosine Kinase Activity on Agonist-induced Contraction in the Rat Pulmonary Vascular Smooth Muscle

✍ J.P. Savineau; P. Gonzalez De La Fuente; R. Marthan 📂 Article 📅 1996 🏛 Elsevier 🌐 English ⚖ 155 KB

In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0