𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole−Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2- b ]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine

✍ Scribed by Ragan, J. A.; Raggon, J. W.; Hill, P. D.; Jones, B. P.; McDermott, R. E.; Munchhof, M. J.; Marx, M. A.; Casavant, J. M.; Cooper, B. A.; Doty, J. L.; Lu, Y.

Book ID
127038135
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
187 KB
Volume
7
Category
Article
ISSN
1083-6160

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Fundamentals of Early Clinical Drug Deve
Fundamentals of Early Clinical Drug Development (From Synthesis Design to Formulation) || Development and Scale-Up of a Heterocyclic Cross-Coupling for the Synthesis of 5-[2-(3-Methyl-3 H -imidazol-4-yl)-thieno[3,2- b ]pyridine-7-yl] amino-2-methyl-1 H -indole
✍ Abdel-Magid, Ahmed F.; Caron, Stéphane 📂 Article 📅 2006 🏛 John Wiley & Sons, Inc. 🌐 English ⚖ 376 KB

Using Recent Examples And Important Case Studies, The Fundamentals Of Early Clinical Drug Development: From Synthesis Design To Formulation Demonstrates The Central Role℗¡that Organic Synthesis Plays In The Early Clinical Evaluation Of Potential Drug Candidates. Reflections On Process Research Ii /

An alternate synthesis of the tat-antago
An alternate synthesis of the tat-antagonist 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine
✍ Hubert Maehr; Gladys Zenchoff; David L. Coffen 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 373 KB

An alternative synthesis of 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine, the compound that inhibits gene expression by HIV-1 at the level of transcriptional transactivation by Tat, has been developed. The process is based on ring expansion of 6-chloro-2-chloromethyl-4-(1H-pyrro