✦ LIBER ✦

Cross-condensation of derivatives of cyanoacetic acid and carbonyl compounds. Part 1: Single-stage synthesis of 1′-substituted 6-amino-spiro-4-(piperidine-4′)-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitriles

✍ Scribed by Anatoliy M Shestopalov; Yuliya M Emeliyanova; Aleksandr A Shestopalov; Lyudmila A Rodinovskaya; Zukhra I Niazimbetova; Dennis H Evans

Book ID: 104205711
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 156 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)01178-5

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✦ Synopsis

To develop a method of synthesis of the potentially physiologically active compounds, 1 0 -substituted 6-amino-spiro-4-(piperidine-4 0 )-2H,4H-pyrano[2,3-c]pyrazoles, we studied the three-component condensation of substituted piperidin-4-ones, malononitrile and pyrazolin-5-ones. It was found that the electrochemical method of synthesis is more regioselective, the products of the reaction are analytically pure and do not require further recrystallization.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

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