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Crohn's disease: genetic susceptibility, bacteria, and innate immunity

✍ Scribed by David A van Heel; Dermot PB McGovern; Derek P Jewell


Book ID
117277411
Publisher
The Lancet
Year
2001
Tongue
English
Weight
68 KB
Volume
357
Category
Article
ISSN
0140-6736

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Background: CBir1 is a dominant antigen with a role in innate and adaptive immunity in mouse models of colitis and antibodies to CBir1 are associated with severe human Crohn's disease (CD). Our aim was to determine whether CBir1 stimulates innate and antigen-specific T-cell responses in CD. We demon