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Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity

✍ Scribed by Mika Yamauchi; Kazuhiro Tsuruma; Shunsuke Imai; Tomohiro Nakanishi; Naofumi Umigai; Masamitsu Shimazawa; Hideaki Hara


Book ID
113589024
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
1001 KB
Volume
650
Category
Article
ISSN
0014-2999

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## Abstract The goal of this study was to assess the in vivo effect of AΞ² on apoptosis pathways involving the endoplasmic reticulum and mitochondria, and its relationship to the induction of tau phosphorylation and DNA oxidative damage. In rabbits treated intracisternally with aggregated AΞ²(1–42),