## Abstract We are interested in two aspects of a given type of metastatic breast cancer: which potentially cancer‐relevant genes are expressed and which factors determine invasiveness. Using reverse transcription real‐time PCR, we detected gene expression of 26 matrix metalloproteinases (MMPs) in
✦ LIBER ✦
Crocetin Inhibits Invasiveness of MDA‐MB‐231 Breast Cancer Cells via Downregulation of Matrix Metalloproteinases
✍ Scribed by Chryssanthi, Dimitra; Dedes, Petros; Karamanos, Nikos; Cordopatis, Paul; Lamari, Fotini
- Book ID
- 125848605
- Publisher
- Thieme Medical Publishers
- Year
- 2010
- Tongue
- German
- Weight
- 197 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0032-0943
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In malignant breast cancer, estrogen metabolism is altered, favoring the accumulation of hydroxyestradiols, which can generate free radicals. These reactive species can activate matrix metalloproteinases (MMPs), which in turn can hydrolyze the proteins of the extracellular matrix (ECM) that act as a