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Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers

✍ Scribed by Joon Ho Ahn; Yang Hu; Michael Hernandez; Jin Ryoun Kim


Book ID
116302350
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
502 KB
Volume
414
Category
Article
ISSN
0006-291X

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✍ Yinon Shafrir; Stewart R. Durell; Andriy Anishkin; H. Robert Guy πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 1010 KB

## Abstract Both soluble and membrane‐bound prefibrillar assemblies of Abeta (AΞ²) peptides have been associated with Alzheimer's disease (AD). The size and nature of these assemblies vary greatly and are affected by many factors. Here, we present models of soluble hexameric assemblies of AΞ²42 and s