Critical Role of Tight Junctions in Drug Delivery across Epithelial and Endothelial Cell Layers

Comparison of the function of the tight

Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer

✍ Shirlette G. Milton; Victoria P. Knutson 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 795 KB

## Abstract In cell culture, both endothelial and epithelial cell monolayers have been found to generate structurally similar tight junctional complexes, as assessed by thin section electron microscopy. Although structurally similar, the tight junctional complexes of the two cell types are, at leas