Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer’s disease (FAD) mutated V717G-APP714–723

Stimulation of G-proteins in human contr

Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP714–723: Implication of oxidative mechanisms

✍ Ello Karelson; Sandra Fernaeus; Katarina Reis; Nenad Bogdanovic; Tiit Land 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract We report the effects of amyloid precursor protein (APP) fragment 714–723 (APP~714–723~; peptide P1) and its V717F and V717G mutants (peptides P2 and P3, respectively) on G‐protein activity ([^35^S]GTPγS binding) in membranes from postmortem human control and Alzheimer's disease (AD) br