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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

✍ Scribed by Foukas, Lazaros C.; Claret, Marc; Pearce, Wayne; Okkenhaug, Klaus; Meek, Stephen; Peskett, Emma; Sancho, Sara; Smith, Andrew J. H.; Withers, Dominic J.; Vanhaesebroeck, Bart


Book ID
109895790
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
589 KB
Volume
441
Category
Article
ISSN
0028-0836

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Role of the phosphoinositide 3-kinase p1
✍ Baher F. Nashed; Tingting Zhang; Monther Al-Alwan; Ganesh Srinivasan; Andrew J. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB

## Abstract Phosphoinositide 3‐kinases (PI3K) regulate immune activation __via__ their roles in signal transduction of multiple classes of receptors. Here, we examined the effect of genetic inactivation of the hemopoietic cell‐restricted PI3K isoform p110δ on systemic cytokine and chemokine respons