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Critical role for NF-κB-induced JunB in VEGF regulation and tumor angiogenesis

✍ Scribed by Schmidt, Dirk; Textor, Björn; Pein, Oliver T; Licht, Alexander H; Andrecht, Sven; Sator-Schmitt, Melanie; Fusenig, Norbert E; Angel, Peter; Schorpp-Kistner, Marina


Book ID
110031919
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
424 KB
Volume
26
Category
Article
ISSN
0261-4189

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The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. PMA increased the synthesis and mRNA levels of FN and its promoter activity in Hep3B hepatoma cells. The PMA-induced activation of FN expression was blocked by a protein