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Critical Role for a Central Part of Mdm2 in the Ubiquitylation of p53

✍ Scribed by Meulmeester, E.; Frenk, R.; Stad, R.; de Graaf, P.; Marine, J.-C.; Vousden, K. H.; Jochemsen, A. G.

Book ID
126861773
Publisher
American Society for Microbiology
Year
2003
Tongue
English
Weight
591 KB
Volume
23
Category
Article
ISSN
0270-7306

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## Abstract The 5th subunit of COP9 signalosome (CSN5, also known as Jab1 or COPS5) is implicated in regulating p53 activity and is overexpressed in various tumors. However, the precise roles of CSN5 in p53 network and tumorigenesis are not well characterized. Here we show that CSN5 is a critical r