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Critical factors in the release of drugs from sustained release hydrophilic matrices

✍ Scribed by Cristina Maderuelo; Aránzazu Zarzuelo; José M. Lanao

Book ID
113694644
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
372 KB
Volume
154
Category
Article
ISSN
0168-3659

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Weakly basic drugs and their salts exhibit a drop in aqueous solubility at high pH conditions, which can result in low and incomplete release of these drugs from sustained release formulations. The objective of this study is to modulate matrix microenvironmental pH by incorporation of acidic polymer