Critical evaluation of the chemical standardization procedure for measuring gastric emptying of solids

✍ Scribed by P. Goethals; A. Volkaert; B. Van Vlem; R. Vanholder

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: French
• Weight: 91 KB
• Volume: 45
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.609

✦ Synopsis

Abstract

The purpose of this study was to evaluate the baking process of yolk spiked with octanoate to measure gastric emptying rate of solids. [1‐^11^C]octanoate was produced by the reaction of [^11^C]CO~2~ with heptyl magnesium bromide in tetrahydrofuran (THF), followed by purification with HPLC. The decay corrected radiochemical yield ranged from 24 to 38% (5.9–9.8 GBq EOS, synthesis time: 25 min; specific radioactivity ∼90 GBq μmol^−1^). To check the evaporation of [1‐^11^C]octanoate during the baking process of yolk, [1‐^11^C]octanoate or potassium [1‐^11^C]octanoate, respectively, was added. An important fraction of the acid evaporated while for the potassium [1‐^11^C]octanoate <10% disappeared. Conclusion: potassium (1‐^13^C)octanoate is a better tracer than (1‐^13^C) octanoate to study gastroenterological phenomena. Copyright © 2002 John Wiley & Sons, Ltd.