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CRH inhibits NF-κB signaling in human melanocytes

✍ Scribed by Blazej Zbytek; Lawrence M. Pfeffer; Andrzej T. Slominski


Book ID
116831208
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
412 KB
Volume
27
Category
Article
ISSN
0196-9781

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The neuropeptide ␣-melanocyte-stimulating hormone (␣-MSH) modulates inflammation by inhibiting production of proinflammatory cytokines. Using a plasmid vector encoding ␣-MSH, we examined whether autocrine ␣-MSH inhibits activation of the nuclear transcription factor NF-B, a factor that is essential