Crescentic Glomerulonephritis and Subepidermal Blisters with Autoantibodies to α5 and α6 Chains of Type IV Collagen
✍ Scribed by Ghohestani, Reza F; Rotunda, Sherry L; Hudson, Billy; Gaughan, William J; Farber, John L; Webster, Guy; Uitto, Jouni
- Book ID
- 110087137
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 852 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0023-6837
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📜 SIMILAR VOLUMES
The basement membrane type IV collagen is a family composed of six genetically distinct but structurally similar polypeptide chains, ␣1-␣6. The ␣1(IV) and ␣2(IV) chains are ubiquitous components of all BMs whereas the other four have a restricted tissue distribution. In the present study, we have an
The anti-glomerular basement membrane (GBM)-nephritis-inducing activity of six synthetic peptides having an amino acid sequence consisting of the six a chains of human type IV collagen was examined by injecting the peptides into rats. The peptides consisted of 27 amino acid residues from the non-col