Creatine phosphokinase activity in dysgenic (mdg/mdg) mouse muscle

✍ Scribed by Francine B. Essien; Cheryl L. Biber

• Book ID: 104783741
• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 440 KB
• Volume: 15
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00483991

✦ Synopsis

The specific activity of creatine phosphokinase (CPK) was measured in the muscle of mdg/mdg and control embryos of 14-18 days' gestation. CPK specific activity values were similar in mutant and normal embryos at the earliest stages examined (14-15 days). However, after 15 1/2 days, the specific activity of the enzyme in the mdg/mdg embryos was approximately 50% lower than in the controls. The dysgenic and normal muscle extracts exhibited comparable stability after storage at -85 C. CPK activity levels in the muscle of adult heterozygotes (+/mdg) and wild-type (+/+) controls were found to be statistically identical. The findings suggest that the mdg mutation does not have a primary or direct effect on CPK activity.