Creatine kinase isoenzyme (CK-BB) by RIA as a follow-up marker in stage D cancer of the prostate: Comparison with PAP RIA

✍ Scribed by Ayda El-Shribiny; Arvind Bharvaga; John Fitzpatrick; Gerald P. Murphy

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 361 KB
• Volume: 28
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930280319

✦ Synopsis

Abstract

Fifty‐nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK‐BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK‐BB as a follow‐up marker compared to PAP. Thirty‐three patients were in stable, 19 in progressive, and seven in regressive clinical state. CK‐BB was above normal level in 52 (88%) out of 59 patients with no statistically significant difference between the three clinical states. On the other hand, PAP was above normal level in only 23 patients (38.98%) with statistically significant difference between the three clinical states (P < 0.001).

The PAP/CK‐BB index was below 1 in stable and regressive condition, while it was above 1 in eight out of 19 patients with progressive disease. The PAP/CK‐BB index may be of prognostic importance. CK‐BB by RIA was abnormal in more cases than PAP. In this way CK‐BB reflects the presence of the tumor and may be used for diagnosis; however, it does not reflect the clinical response as PAP does.