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Craniosynostosis, Philadelphia type: A new autosomal dominant syndrome with sagittal craniosynostosis and syndactyly of the fingers and toes

✍ Scribed by Robin, Nathaniel H.; Segel, Barbara; Carpenter, Gary; Muenke, Maximilian


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
74 KB
Volume
62
Category
Article
ISSN
0148-7299

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✦ Synopsis


The acrocephalosyndactyly syndromes (ACS) are a group of clinically similar disorders that share the manifestations of craniosynostosis and a variety of hand and foot anomalies. Here we report on a 5-generation kindred segregating sagittal craniosynostosis and syndactyly of the fingers and the toes in an autosomal dominant manner. The anomalies seen in this kindred comprise a syndrome distinct from other craniosynostosis syndromes. For this novel syndrome, we propose the name craniosynostosis, Philadelphia type.