Increasing the flux in metabolic pathway
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David A. Fell
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Article
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1998
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John Wiley and Sons
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English
β 32 KB
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The problems of engineering increased flux in metabolic pathways are analyzed in terms of the understanding provided by metabolic control analysis. Overexpression of a single enzyme is unlikely to be effective unless it is known to have a high flux control coefficient, which can be used as an approx