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Coxsackie A9 Virus: Mutation from Drug Dependence to Drug Independence

✍ Scribed by Eggers, H. J.; Tamm, I.

Book ID: 121173801
Publisher: American Association for the Advancement of Science
Year: 1965
Tongue: English
Weight: 540 KB
Volume: 148
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.148.3666.97

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## Abstract An assay for the analysis of point mutations in DNA fragments amplified by the polymerase chain reaction is described. The method was applied to the analysis of mutations leading to single amino acid changes in the reverse transcriptase gene of human immunodeficiency virus type‐1 that a