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COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells

✍ Scribed by Ugochukwu C. Nzeako; Maria Eugenia Guicciardi; Jung-Hwan Yoon; Steven F. Bronk; Gregory J. Gores

Book ID
111721766
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
467 KB
Volume
35
Category
Article
ISSN
0270-9139

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## Abstract Human cholangiocarcinoma is a malignancy with no effective therapy and a poor prognosis. Previously, we demonstrated that cultured human cholangiocarcinoma cell lines heterogeneously express Fas on their surface, resulting in 2 subpopulations, Fas‐high and Fas‐low cells. Fas‐low cells a